Alloimmunization and autoimmunization in transfusion dependent thalassemia major patients: Study on 319 patients
نویسندگان
چکیده
منابع مشابه
Alloimmunization and erythrocyte autoimmunization in transfusion-dependent thalassemia patients of predominantly asian descent.
The development of hemolytic alloantibodies and erythrocyte autoantibodies complicates transfusion therapy in thalassemia patients. The frequency, causes, and prevention of this phenomena among 64 transfused thalassemia patients (75% Asian) were evaluated. The effect of red blood cell (RBC) phenotypic differences between donors (mostly white) and Asian recipients on the frequency of alloimmuniz...
متن کاملassessment of frequency of alloimmunization and erythrocyte autoimmunization in transfusion dependent thalassemia patients
life-long red blood transfusion remains the main treatment for severe thalassemia. the development of hemolytic alloantibodies and erythrocyte autoantibodies complicated transfusion therapy in thalassemia patients. the frequency causes and prevention of this phenomenon among 80 transfused thalassemia patients were evaluated in ali asghar children's hospital during 1998-2004 in a cross-sectional...
متن کاملCLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Alloimmunization and erythrocyte autoimmunization in transfusion-dependent thalassemia patients of predominantly Asian descent
The development of hemolytic alloantibodies and erythrocyte autoantibodies complicates transfusion therapy in thalassemia patients. The frequency, causes, and prevention of this phenomena among 64 transfused thalassemia patients (75% Asian) were evaluated. The effect of red blood cell (RBC) phenotypic differences between donors (mostly white) and Asian recipients on the frequency of alloimmuniz...
متن کاملAlloimmunization in Hong Kong southern Chinese transfusion-dependent thalassemia patients.
factor-a, which increase endothelial expression of E-selectin. These molecules tether rolling neutrophils by binding to granulocyte Lewis x sialyated carbohydrate (CD15). This allows neutrophil integrins such as complement receptor 3 (CD11b) to adhere to the endothelium via interaction with its ligand intercellular adhesion molecule-1.7 The importance of CD64 (Fc-gamma receptor I) as a marker o...
متن کاملRed Blood Cells Alloimmunization and Autoimmunization in Multi-transfused Thalassemia Patients in South of Iran
Background: Recurrent blood transfusion is a common treatment in patients with thalassemia. The development of antibodies against red blood cell (RBC) antigens complicates RBC cross-matching, enhances the in vivo destruction of transfused cells, accelerates tissue iron overloading, delays the provision of safe transfusion, and reduces health-related quality of life. Materials and Methods: In t...
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ژورنال
عنوان ژورنال: Asian Journal of Transfusion Science
سال: 2014
ISSN: 0973-6247
DOI: 10.4103/0973-6247.137438